Kinetics of Insulin Release from the Perfused Rat Pancreas Caused by Glucose, Glucosamine, and Galactose

Under appropriate conditions, not only glucose but also glucosamine and galactose can serve as potent stimulants for insulin release from the isolated, perfused rat pancreas. Since galactose and, probably, glucosamine are not metabolized in the islets, and since these three compounds have in all lik...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1971-03, Vol.68 (3), p.536-540
Main Authors: Landgraf, Rudiger, Kotler-Brajtburg, Janina, Matschinsky, Franz M.
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
Animals
Biological Sciences: Physiology
Diabetes mellitus
Insulin
Islets of Langerhans
Kinetics
Metabolism
Pancreas
Perfusion
Receptors
Secretion
Sugars
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Summary:Under appropriate conditions, not only glucose but also glucosamine and galactose can serve as potent stimulants for insulin release from the isolated, perfused rat pancreas. Since galactose and, probably, glucosamine are not metabolized in the islets, and since these three compounds have in all likelihood common sites of action, it is postulated that a glucoreceptor of broad specificity is involved in the mechanism of insulin release, and that metabolism of glucose is not an essential part of the releasing action of this sugar.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.68.3.536