Chemical Transformation of Rat Cells Infected with Xenotropic Type-C RNA Virus and Its Suppression by Virus-Specific Antiserum

Fischer rat embryo cells infected with xenotropic mouse type-C RNA viruses isolated from either NIH Swiss mice or C57L inbred mice were transformed by 4-nitroquinoline oxide or 3-methylcholanthrene under conditions in which neither treatment alone sufficed to induce transformation. Transformation wa...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1977-02, Vol.74 (2), p.579-581
Main Authors: Price, Paul J., Suk, William A., Peters, Robert L., Gilden, Raymond V., Huebner, Robert J.
Format: Article
Language:English
Subjects:
Animals
B lymphocytes
Carcinogens
Cell Line
Cell Transformation, Neoplastic
Cells
Chemical treatment
Embryonic cells
Embryos
Immune Sera
Oncogenic Viruses - immunology
Phenotype
Rats
RNA viruses
RNA Viruses - immunology
Subcultures
Tumors
Viruses
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Description
Summary:Fischer rat embryo cells infected with xenotropic mouse type-C RNA viruses isolated from either NIH Swiss mice or C57L inbred mice were transformed by 4-nitroquinoline oxide or 3-methylcholanthrene under conditions in which neither treatment alone sufficed to induce transformation. Transformation was dependent on the presence of actively growing virus at the time of chemical treatment. Specific antibody to xenotropic virus neutralized the virus and inhibited malignant transformation by 3-methylcholanthrene.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.74.2.579