Characterization of a Delta-Electroencephalogram(-Sleep)-Inducing Peptide

A peptide that induces slow-wave (delta) and spindles electroencephalogram enhancement after intraventricular (brain) infusion has been isolated from rabbits and given the name delta-sleep-inducing peptide (DSIP). Amino acid sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This compound, five possible...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1977-03, Vol.74 (3), p.1282-1286
Main Authors: Schoenenberger, Guido A., Monnier, Marcel
Format: Article
Language:English
Subjects:
Acoustic spectra
Animals
Computer systems
Control groups
Delta Rhythm
Electroencephalography
Factor analysis
Injections, Intraventricular
Lead
Neocortex
Oligopeptides - administration & dosage
Oligopeptides - pharmacology
Rabbits
Sleep
Sleep - drug effects
Structure-Activity Relationship
Vibrational frequencies
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Description
Summary:A peptide that induces slow-wave (delta) and spindles electroencephalogram enhancement after intraventricular (brain) infusion has been isolated from rabbits and given the name delta-sleep-inducing peptide (DSIP). Amino acid sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This compound, five possible metabolic products (containing residues 1-8, 2-9, 2-8, 1-4, and 5-9), two nonapeptide analogues with two amino acids exchanged, and a related tripeptide (Trp-Ser-Glu) were synthesized. All nine synthetic peptides were infused intraventricularly in rabbits under double-blind conditions. A total of 58 rabbits including controls were evaluated. The electroencephalogram leads from the neocortex and the archicortex were directly fast-Fourier transformed and analyzed by a Univac 1108 computer system. Only the delta-sleep-inducing peptide (synthetic) showed significant and specific enhancement/induction of delta and spindle electroencephalogram patterns.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.74.3.1282