Linkage Analyses of Multiple Endocrine Neoplasia, Type 2 (MEN-2) with 23 Classical Genetic Polymorphisms

Linkage analyses were performed in a single large family with multiple endocrine neoplasia, type 2 (MEN-2) between 23 classical genetic polymorphisms and MEN-2. We exclude close linkage of the locus for MEN-2 with ABO, ACPl, BF, ESD, Fy, GALT, GLOl, Jk, MNSs, P, PGMl, Rh and TF, as well as absolute...

Full description

Saved in:
Bibliographic Details
Published in:Human heredity 1986-01, Vol.36 (1), p.6-11
Main Authors: Kruger, Susan D., Gertner, Joseph M., Sparkes, Robert S., Haedt, Lori E., Crist, Michol, Sparkes, Maryellen C., Genel, Myron, Kidd, Kenneth K.
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Endocrinopathies
Female
Gene Frequency
Genes, Dominant
Genetic Linkage
Humans
Male
Malignant tumors
Medical sciences
Multiple Endocrine Neoplasia - genetics
Original Paper
Original Papers
Pedigree
Phenotype
Polymorphism, Genetic
Thyroid. Thyroid axis (diseases)
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Linkage analyses were performed in a single large family with multiple endocrine neoplasia, type 2 (MEN-2) between 23 classical genetic polymorphisms and MEN-2. We exclude close linkage of the locus for MEN-2 with ABO, ACPl, BF, ESD, Fy, GALT, GLOl, Jk, MNSs, P, PGMl, Rh and TF, as well as absolute linkage with GPT. These results raise to about 6% the proportion of the genome that has been excluded in this one family. Somewhat positive lod scores were obtained for GC (0.92 at Θ̂ = 0), GPT(0.73 at Θ̂ = 0.1) and HP (1.49 at Θ̂ = 0.05); although not statistically significant, these findings suggest regions of the genome that warrant additional study.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153592