Human Enzyme Polymorphism in the Canary Islands

Sequence analysis of the glucose-6-phosphate dehydrogenase (G6PD) variant Gc, characterized by slower electrophoretic mobility than G6PD-B, in 14 Canarian and 2 Berber males, has revealed that all of them share the G → C mutation at nucleotide 844 in exon 8 leading to an Asp → His substitution at am...

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Bibliographic Details
Published in:Human heredity 1996-01, Vol.46 (4), p.197-200
Main Authors: Cabrera, V.M., González, P., Salo, W.L.
Format: Article
Language:English
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Summary:Sequence analysis of the glucose-6-phosphate dehydrogenase (G6PD) variant Gc, characterized by slower electrophoretic mobility than G6PD-B, in 14 Canarian and 2 Berber males, has revealed that all of them share the G → C mutation at nucleotide 844 in exon 8 leading to an Asp → His substitution at amino acid 282 known as G6PD Seattle. No additional differences have been detected among them nor with the common haplotype previously found for this variant.
ISSN:0001-5652
1423-0062
DOI:10.1159/000154353