Utilisation du fructose par I'hépatocyte isolé de rat nourri Zucker obèse fa/fa

The utilization of fructose by isolated hepatocytes was investigated in fed obese Zucker fa/fa rats compared with their lean littermates (Fa/?) and Sprague-Dawley rats. Hepatocytes were incubated during 3 h using U 14 C fructose (20 mM). Our results show: a significant increase of fructose consumpti...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 1985-02, Vol.29 (2), p.119-128
Main Authors: Serbource-Goguel, Nathalie, Porquet, Dominique, Feger, Jeanne, Durand, Geneviêve, Appel, Marline, Agneray, Jean
Format: Article
Language:English
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Summary:The utilization of fructose by isolated hepatocytes was investigated in fed obese Zucker fa/fa rats compared with their lean littermates (Fa/?) and Sprague-Dawley rats. Hepatocytes were incubated during 3 h using U 14 C fructose (20 mM). Our results show: a significant increase of fructose consumption, glucose, lactate and pyruvate production and faster turnover of glycogen by fa/fa rats. In these animals, synthesis of acylglycerol was also significantly enhanced. Our results suggest that fructose in fa/fa rats was used preferentially as precursor for lipid synthesis not only by the liver but also by the adipose tissue after a prior transformation into glucose by hepatocytes. All these abnormalities result in an accumulation of acylglycerols maintaining an obesity state in fa/fa rats.
ISSN:0250-6807
1421-9697
DOI:10.1159/000176969