Effect of thiamin status on the metabolism of linamarin in rats

The effect of graded levels of thiamin on the metabolism of linamarin was investigated in rats. It was observed that on a diet deficient in thiamin, a large amount of linamarin was recovered unchanged in the urine, together with significantly more thiocyanate (SCN⁻) relative to the control. The leas...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 1985-01, Vol.29 (5), p.319-324
Main Authors: Umoh, I.B., Ogunkoya, F.O., Maduagwu, E.N., Oke, O.L.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cyanides - urine
linamarin
Manihot
Medical sciences
Metabolic diseases
Nervous System Diseases - etiology
Nitriles - metabolism
nutritional status
Original Paper
Original Papers
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Rats
Rats, Inbred Strains
thiamin
Thiamine - administration & dosage
Thiamine - pharmacology
Thiamine Deficiency - complications
Thiamine Deficiency - metabolism
Thiocyanates - urine
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Summary:The effect of graded levels of thiamin on the metabolism of linamarin was investigated in rats. It was observed that on a diet deficient in thiamin, a large amount of linamarin was recovered unchanged in the urine, together with significantly more thiocyanate (SCN⁻) relative to the control. The least amount of thiocyanate (p < 0.05 relative to control) was found in animals receiving the highest amount (twice daily requirement) of thiamin in the diet; but the amount of unmetabolized linamarin was similar to the control. It is suggested that thiamin deficiency may be implicated in the aetiology of tropical ataxic neuropathy (TAN) through the thiocyanate overload in people eating large amounts of cassava and cassava derivatives which contain linamarin.
ISSN:0250-6807
1421-9697
DOI:10.1159/000176987