Simultaneous Measurement of Brain and Core Temperature in the Rat during Fever, Hyperthermia, Hypothermia and Sleep

The neuropathological outcome of metabolic, vascular or mechanical insults to the CNS depends on brain temperature; mild hypothermia is neuroprotective, whereas elevated brain temperature can cause additional neural damage. Studies in both animals and humans have shown that the core and the brain te...

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Bibliographic Details
Published in:Neuroimmunomodulation 1998-09, Vol.5 (5), p.241-247
Main Authors: Sundgren-Andersson, Anna K., Östlund, Pernilla, Bartfai, Tamas
Format: Article
Language:English
Subjects:
8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology
Animals
Body Temperature - physiology
Brain - physiology
Circadian Rhythm
Fever - chemically induced
Fever - physiopathology
Humans
Hypothermia - chemically induced
Hypothermia - physiopathology
Interleukin-1 - pharmacology
Male
Original Paper
Rats
Rats, Sprague-Dawley
Recombinant Proteins - pharmacology
Sleep - physiology
Stress, Physiological - complications
Telemetry - instrumentation
Telemetry - methods
Thermography - instrumentation
Thermography - methods
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Summary:The neuropathological outcome of metabolic, vascular or mechanical insults to the CNS depends on brain temperature; mild hypothermia is neuroprotective, whereas elevated brain temperature can cause additional neural damage. Studies in both animals and humans have shown that the core and the brain temperature do not always concur with one another. It is therefore important to develop methods for monitoring brain temperature. This paper describes an animal model (the rat) in which we have developed a method to measure, at thermoneutral ambient temperature, the brain and core temperature concomitantly, during different drug treatments. We have used this animal model to study body temperature during fever (induced by human recombinant IL-1β, 5 µg/kg, i.p.), stress-induced hyperthermia (handling of the animal), hypothermia (induced by (±)-8-hydroxy-2-dipropylaminotetralin hydrobromide, 0.5 mg/kg, i.p.) and sleep (non-induced, other than by light and diurnal variation). We show that the thermal curves are similar in the brain and the peritoneum, independent of the thermal state.
ISSN:1021-7401
1423-0216
DOI:10.1159/000026344