Summary Report on the ISOBM TD-6 Workshop: Analysis of 20 Monoclonal Antibodies against Sialyl Lewisa and Related Antigens

The ISOBM TD-6 Workshop is the first international workshop on monoclonal antibodies against the Sialyl Lewis a (SLe a ) antigen. Eight research groups participated in a blind study to characterize the epitope binding, relative affinity and performance in immunoradiometric assays, of a panel of 20 m...

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Published in:Tumor biology 1998-05, Vol.19 (5), p.390-420
Main Authors: Rye, P.D., Bovin, N.V., Vlasova, E.V., Molodyk, A.A., Baryshnikov, A., Kreutz, F.T., Garinther, W.I., Schultes, B.C., Noujaim, A.A., Madiyalakan, R., Magnani, J., Nilsson, O., Nilsson, K., Nustad, K., Norum, L., Bell, H., Cao, Y., Suresh, M.R., Very, D.L., Freeman, J.V., Yeung, K.K., Hilgers, J.
Format: Article
Language:English
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Workshop Report
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Summary:The ISOBM TD-6 Workshop is the first international workshop on monoclonal antibodies against the Sialyl Lewis a (SLe a ) antigen. Eight research groups participated in a blind study to characterize the epitope binding, relative affinity and performance in immunoradiometric assays, of a panel of 20 monoclonal antibodies. The antibodies were tested against a diverse panel of neoglycoconjugates, purified antigens and human serum pools from gastrointestinal malignancies. Epitope specificities were determined for the majority of antibodies in the panel. Cross-reactivity with related saccharide structures was noted in several antibodies. Overall, the results of the TD-6 Workshop show further development of SLe a immunoassays may yield yet more specific assays for the detection and management of gastrointestinal and other malignancies.
ISSN:1010-4283
1423-0380
DOI:10.1159/000030032