Evaluation of Solvent/Detergent-Treated Plasma in Patients with a Prolonged Prothrombin Time

Objectives: To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP). Methods: A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to ≤15 s in patients...

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Bibliographic Details
Published in:Vox sanguinis 2000-03, Vol.79 (3), p.161-167
Main Authors: Lerner, R.G., Nelson, J., Sorcia, E., Grima, K., Kancherla, R.R., Zarou-Naimo, C.M., Pehta, J.C.
Format: Article
Language:English
Subjects:
Labile Blood Components and Blood Donation
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Summary:Objectives: To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP). Methods: A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to ≤15 s in patients with acquired coagulation deficits. Results: 45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to ≤15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP). Conclusion: No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.
ISSN:0042-9007
1423-0410
DOI:10.1159/000031235