Association of Chronic Kidney Disease and Cerebral Small Vessel Disease with Cognitive Impairment in Elderly Patients with Type 2 Diabetes

Background/Aims: In recent years, the relationship between chronic kidney disease (CKD) and cognitive impairment has been attracting attention. Cerebral small vessel disease (SVD) is also associated with an increased risk of cognitive impairment. However, it is still unknown whether CKD markers are...

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Published in:Dementia and geriatric cognitive disorders extra 2013-07, Vol.3 (1), p.212-222
Main Authors: Umemura, Toshitaka, Kawamura, Takahiko, Umegaki, Hiroyuki, Kawano, Naoko, Mashita, Shinichi, Sakakibara, Toshimasa, Hotta, Nigishi, Sobue, Gen
Format: Article
Language:English
Subjects:
Albuminuria
Cerebral small vessel disease
Chronic kidney disease
Cognitive impairment
Diabetes
Elderly
Glomerular filtration rate
Magnetic resonance imaging
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Original Research Article
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Summary:Background/Aims: In recent years, the relationship between chronic kidney disease (CKD) and cognitive impairment has been attracting attention. Cerebral small vessel disease (SVD) is also associated with an increased risk of cognitive impairment. However, it is still unknown whether CKD markers are associated with cognitive impairment independently of SVD in elderly diabetic patients. Methods: Seventy-nine type 2 diabetic patients (mean age, 76.0 years) were enrolled in the present study. CKD was defined as the presence of albuminuria and/or a low estimated glomerular filtration rate (eGFR
ISSN:1664-5464
1664-5464
DOI:10.1159/000351424