RHD PCR of D-Negative Blood Donors

RHD PCR of blood donors may be used to reveal weak D, partial D, DEL and chimeric D+/D- donors among presumed D-negative blood donors. Units donated by such donors pose a definite yet low risk for anti-D immunization of transfusion recipients. The frequency of DEL donors among D-negative donors is 1...

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Bibliographic Details
Published in:Transfusion medicine and hemotherapy 2013-06, Vol.40 (3), p.172-181
Main Author: Wagner, Franz F.
Format: Article
Language:English
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Review
Review Article
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Summary:RHD PCR of blood donors may be used to reveal weak D, partial D, DEL and chimeric D+/D- donors among presumed D-negative blood donors. Units donated by such donors pose a definite yet low risk for anti-D immunization of transfusion recipients. The frequency of DEL donors among D-negative donors is 1:350 to 1:2,000 in Europe and up to 1:5 in Asian countries. Different strategies for RHD PCR of blood donors have been used. Probably, the most cost-efficient implementation is replacement of sensitive D antigen testing with the indirect antiglobulin test by RHD PCR in pools which might even reduce total testing cost.
ISSN:1660-3796
1660-3818
DOI:10.1159/000351604