The Association of Openness Personality Trait with Stress-Related Salivary Biomarkers in Burning Mouth Syndrome

Background: Burning mouth syndrome (BMS) is a chronic disorder defined as a burning sensation in the oral mucosa without evidence of pathological findings. Its pathophysiology is largely unknown, but psychiatric disorders and personality traits have been implicated. Objective: This study investigate...

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Published in:Neuroimmunomodulation 2015-01, Vol.22 (4), p.250-255
Main Authors: de Souza, Fabrício T.A., Kummer, Arthur, Silva, Maiza L.V., Amaral, Tânia M.P., Abdo, Evandro N., Abreu, Mauro H.N.G., Silva, Tarcília A., Teixeira, Antônio L.
Format: Article
Language:English
Subjects:
Aged
Anxiety Disorders - physiopathology
Biomarkers - metabolism
Brain-Derived Neurotrophic Factor - metabolism
Burning Mouth Syndrome - metabolism
Burning Mouth Syndrome - physiopathology
Cross-Sectional Studies
Female
Humans
Hydrocortisone - metabolism
Interleukin-10 - metabolism
Interleukin-6 - metabolism
Male
Middle Aged
Nerve Growth Factor - metabolism
Neuroticism
Original Paper
Personality - physiology
Saliva - chemistry
Stress, Psychological - metabolism
Stress, Psychological - physiopathology
Tumor Necrosis Factor-alpha - metabolism
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Summary:Background: Burning mouth syndrome (BMS) is a chronic disorder defined as a burning sensation in the oral mucosa without evidence of pathological findings. Its pathophysiology is largely unknown, but psychiatric disorders and personality traits have been implicated. Objective: This study investigated whether there is any association between salivary biomarkers and personality traits in BMS patients. Methods: It was a cross-sectional, controlled study that evaluated 30 individuals with BMS and 32 controls. All subjects were assessed with a structured psychiatric interview (Mini International Neuropsychiatric Interview) and the Big Five inventory. Salivary levels of brain-derived neurotrophic factor (BDNF), neural growth factor, tumor necrosis factor-α, interleukin (IL)-6, IL-10 and cortisol were determined. Results: We found that BMS patients exhibited more traits of neuroticism and lower openness than controls. Openness showed a moderate and negative correlation with cortisol, BDNF and IL-6. Conclusion: Personality traits are associated with salivary biomarkers in BMS.
ISSN:1021-7401
1423-0216
DOI:10.1159/000367714