A Follow-Up Study of 50 Chronic Hepatitis C Patients: Adiponectin as a Resilience Biomarker for Major Depression

Objective: Major depression (MD) is a condition associated with both hepatitis C virus (HCV) infection and pegylated interferon (IFN)-α treatment. IFN induces a depressive syndrome that is associated with an inflammatory profile. We aimed to investigate whether there is any specific alteration in pl...

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Bibliographic Details
Published in:Neuroimmunomodulation 2016-01, Vol.23 (2), p.88-97
Main Authors: Fábregas, Bruno C., Vieira, Érica L.M., Moura, Alexandre S., Carmo, Ricardo A., Ávila, Renata E., Abreu, Mery N.S., Prossin, Allan R., Teixeira, Antônio L.
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adult
Antiviral Agents - therapeutic use
Biomarkers - blood
Depressive Disorder, Major - blood
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - psychology
Female
Follow-Up Studies
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - psychology
Humans
Interferon-alpha - therapeutic use
Longitudinal Studies
Male
Middle Aged
Original Paper
Resilience, Psychological
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Summary:Objective: Major depression (MD) is a condition associated with both hepatitis C virus (HCV) infection and pegylated interferon (IFN)-α treatment. IFN induces a depressive syndrome that is associated with an inflammatory profile. We aimed to investigate whether there is any specific alteration in plasma biomarkers associated with MD. Methods: HCV-monoinfected patients, with and without IFN treatment, were followed up for 18 months and went through structured psychiatric evaluation. We assessed plasma levels of brain-derived neurotrophic factor, tumor necrosis factor (TNF) and its soluble type 1 and type 2 receptors (sTNFR1 and sTNFR2, respectively), and adipokines (adiponectin, leptin and resistin) using ELISA. Results: Among the 50 patients included in the study, 14 were treated with IFN during the follow-up. Being older, not married, presenting higher body mass index, higher liver inflammatory activity, lower baseline adiponectin levels and use of IFN were associated with MD development. Higher levels of sTNFR1 during IFN treatment were associated with sustained virological response. The lack of a control group without HCV infection did not allow any assumption of a biomarker change exclusively due to the infection itself. Conclusion: Adiponectin may be a resilience biomarker for MD in HCV-infected patients.
ISSN:1021-7401
1423-0216
DOI:10.1159/000444531