Docetaxel Retinopathy: A Case Report

Background: To report the use of En-face optical coherence tomography (OCT) in a patient treated with docetaxel and tamoxifen for breast cancer for the detection of macular edema (ME) without evidence of leakage on fluorescein angiography (FA). Case Presentation: A 52-year-old woman treated for brea...

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Bibliographic Details
Published in:Case reports in ophthalmology 2017-01, Vol.8 (1), p.21-25
Main Authors: Nghiem-Buffet, Sylvia, Cohen, Salomon Yves, Giocanti-Auregan, Audrey
Format: Article
Language:English
Subjects:
Breast cancer
Cancer therapies
Case Report
Case reports
Cavitation
Chemotherapy
Cysts
Edema
En-face OCT
Family medical history
Macular edema
Medical imaging
Ophthalmology
Patients
Retina
Tamoxifen
Taxanes
Tomography
Toxic retinopathy
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Summary:Background: To report the use of En-face optical coherence tomography (OCT) in a patient treated with docetaxel and tamoxifen for breast cancer for the detection of macular edema (ME) without evidence of leakage on fluorescein angiography (FA). Case Presentation: A 52-year-old woman treated for breast cancer presented with bilateral visual loss for 2 months. FA showed no significant leakage while spectral-domain OCT scans of both eyes showed foveolar and parafoveolar cystic spaces in a moderately thickened macula. En-face OCT segmented at the inner retina showed the petaloid arrangement of cystic cavities, comparable to a cystoid ME. Conclusions: The combined use of tamoxifen could have potentiated the toxic effect of docetaxel on the macula. En-face OCT images may reveal a petaloid aspect of the macula due to cysts in the inner retina segmentation, when FA shows no leakage.
ISSN:1663-2699
1663-2699
DOI:10.1159/000455088