Urinary Angiotensinogen and Renin Excretion are Associated with Chronic Kidney Disease

Background/Aims: Several studies sought to identify new biomarkers for chronic kidney disease (CKD). As the renal renin-angiotensin system is activated in CKD, urinary angiotensinogen or renin excretion may be suitable candidates. We tested whether urinary angiotensinogen or renin excretion is eleva...

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Bibliographic Details
Published in:Kidney & blood pressure research 2017-05, Vol.42 (1), p.145-155
Main Authors: Juretzko, Annett, Steinbach, Antje, Hannemann, Anke, Endlich, Karlhans, Endlich, Nicole, Friedrich, Nele, Lendeckel, Uwe, Stracke, Sylvia, Rettig, Rainer
Format: Article
Language:English
Subjects:
Aged
Albumin
Albuminuria
Angiotensin
Angiotensinogen
Angiotensinogen - urine
Biomarkers
Biomarkers - urine
Blood pressure
Body mass
Body mass index
Body size
Case-Control Studies
Chronic kidney disease
Correlation coefficients
Creatinine
Diuretics
Epidemiology
Epidermal growth factor receptors
Excretion
Family medical history
Female
Glomerular Filtration Rate
Humans
Kidney diseases
Laboratories
Male
Measurement methods
Middle Aged
Original Paper
Parameter estimation
Patients
Population
Precision medicine
Proteins
Regression analysis
Regression models
Renal Insufficiency, Chronic - urine
Renin
Renin - urine
Renin-angiotensin system
ROC Curve
Rodents
Standard error
Studies
Urine
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Summary:Background/Aims: Several studies sought to identify new biomarkers for chronic kidney disease (CKD). As the renal renin-angiotensin system is activated in CKD, urinary angiotensinogen or renin excretion may be suitable candidates. We tested whether urinary angiotensinogen or renin excretion is elevated in CKD and whether these parameters are associated with estimated glomerular filtration rate (eGFR). We further tested whether urinary angiotensinogen or renin excretion may convey additional information beyond that provided by albuminuria. Methods: We measured urinary and plasma angiotensinogen, renin, albumin and creatinine in 177 CKD patients from the Greifswald Approach to Individualized Medicine project and in 283 healthy controls from the Study of Health in Pomerania. The urinary excretion of specific proteins is given as protein-to-creatinine ratio. Receiver operating characteristic (ROC) curves, spearman correlation coefficients and linear regression models were calculated. Results: Urinary angiotensinogen [2,511 (196-31,909) vs. 18.6 (8.3-44.0) pmol/g, *P
ISSN:1420-4096
1423-0143
DOI:10.1159/000474932