Contraction and intracellular Ca2+ in ventricular myocytes from rats receiving fructose-enriched diets

Contraction and intracellular Ca 2+ in ventricular myocytes from rats receiving fructose-enriched diets (FED) were investigated. Groups of male Wistar rats received normal rat chow together with either normal drinking water or water containing 500 mM fructose ad libitum. Experiments were performed 1...

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Published in:Dubai diabetes and endocrinology journal 2019-03, Vol.11 (3), p.62-66
Main Authors: Howarth, F.C., Qureshi, A., Al-Mansoori, D., Ponery, A.S., Naseer, O., Adeghate, E.
Format: Article
Language:English
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Summary:Contraction and intracellular Ca 2+ in ventricular myocytes from rats receiving fructose-enriched diets (FED) were investigated. Groups of male Wistar rats received normal rat chow together with either normal drinking water or water containing 500 mM fructose ad libitum. Experiments were performed 12-14 weeks later. Rats receiving FED responded differently to a standard glucose tolerance test. Fasting blood glucose levels in FED and control rats were 48.5±2.3 (4) and 47.0±1.9 (4) mg/dl, respectively. At 30 min after intraperitoneal administration of glucose (2g/kg body weight), concentrations of blood glucose were significantly (p
ISSN:2673-1797
2673-1738
DOI:10.1159/000497553