Tamoxifen Exposure during Pregnancy: A Systematic Review and Three More Cases

Tamoxifen is frequently used as adjuvant treatment in premenopausal patients with hormone receptor-positive early breast cancer. According to guidelines, the use of nonhormonal barrier contraception is recommended during tamoxifen treatment and up to 3 months after its interruption prior to attempti...

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Published in:Breast care (Basel, Switzerland) Switzerland), 2020-04, Vol.15 (2), p.148-156
Main Authors: Buonomo, Barbara, Brunello, Antonella, Noli, Stefania, Miglietta, Loredana, Del Mastro, Lucia, Lambertini, Matteo, Peccatori, Fedro Alessandro
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Systematic Review
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container_title Breast care (Basel, Switzerland)
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creator Buonomo, Barbara
Brunello, Antonella
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description Tamoxifen is frequently used as adjuvant treatment in premenopausal patients with hormone receptor-positive early breast cancer. According to guidelines, the use of nonhormonal barrier contraception is recommended during tamoxifen treatment and up to 3 months after its interruption prior to attempting conception. Nevertheless, when conception occurs inadvertently during tamoxifen treatment, the effects on the fetus and on the course of pregnancy are still not completely known. Here, we report 3 cases of young women who accidentally became pregnant while taking tamoxifen and perform a systematic review of the literature to provide more elements for better and clear multidisciplinary counselling of women facing this challenging situation.
doi_str_mv 10.1159/000501473
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title Tamoxifen Exposure during Pregnancy: A Systematic Review and Three More Cases
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