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Intravitreal Voriconazole for Treatment of Bilateral Endogenous Candida Chorioretinitis
This report describes a patient with bilateral endogenous candida chorioretinitis. The patient had a 2-day history of bilateral blurred vision. Fundus photography revealed multiple chorioretinal infiltrations in both eyes and a parafoveal hemorrhage in the left eye. After 2 days, fundus examination...
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Published in: | Case reports in ophthalmology 2020-08, Vol.11 (2), p.402-410 |
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description | This report describes a patient with bilateral endogenous candida chorioretinitis. The patient had a 2-day history of bilateral blurred vision. Fundus photography revealed multiple chorioretinal infiltrations in both eyes and a parafoveal hemorrhage in the left eye. After 2 days, fundus examination showed an increased number of infiltrations and hemorrhages in both eyes and worsening vitreous inflammation. A large infiltrative intraretinal lesion and a retinal hemorrhage of the left eye were discovered on optical coherence tomography. Candida albicans was diagnosed from blood culture. The bilateral candida chorioretinitis had not responded to systemic or topical antifungal medication. The chorioretinitis was refractory to intravitreal amphotericin B as well. Intravitreal voriconazole injection in both eyes and intravitreal bevacizumab injection in the left eye were performed thereafter. The chorioretinal infiltrations and hemorrhages decreased in both eyes. Intravitreal voriconazole injection was effective in the treatment of intractable candida chorioretinitis. |
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The patient had a 2-day history of bilateral blurred vision. Fundus photography revealed multiple chorioretinal infiltrations in both eyes and a parafoveal hemorrhage in the left eye. After 2 days, fundus examination showed an increased number of infiltrations and hemorrhages in both eyes and worsening vitreous inflammation. A large infiltrative intraretinal lesion and a retinal hemorrhage of the left eye were discovered on optical coherence tomography. Candida albicans was diagnosed from blood culture. The bilateral candida chorioretinitis had not responded to systemic or topical antifungal medication. The chorioretinitis was refractory to intravitreal amphotericin B as well. Intravitreal voriconazole injection in both eyes and intravitreal bevacizumab injection in the left eye were performed thereafter. The chorioretinal infiltrations and hemorrhages decreased in both eyes. Intravitreal voriconazole injection was effective in the treatment of intractable candida chorioretinitis.</description><identifier>ISSN: 1663-2699</identifier><identifier>EISSN: 1663-2699</identifier><identifier>DOI: 10.1159/000508912</identifier><identifier>PMID: 32999668</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Antifungal agents ; candida chorioretinitis ; Case Report ; Case reports ; Catheters ; Chemotherapy ; Conflicts of interest ; endogenous chorioretinitis ; Fever ; Hemorrhage ; Internal medicine ; Intravenous therapy ; Medicine ; Monoclonal antibodies ; Oral administration ; Patients ; Substance abuse treatment ; Tomography ; voriconazole</subject><ispartof>Case reports in ophthalmology, 2020-08, Vol.11 (2), p.402-410</ispartof><rights>2020 The Author(s). Published by S. Karger AG, Basel</rights><rights>Copyright © 2020 by S. Karger AG, Basel 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-c30b210dd4ca233b69b4c857bda8ca95e5b686fc3f180194d1b2ca7a76fc44493</citedby><cites>FETCH-LOGICAL-c529t-c30b210dd4ca233b69b4c857bda8ca95e5b686fc3f180194d1b2ca7a76fc44493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506273/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506273/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27635,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Sim, Ha Eun</creatorcontrib><creatorcontrib>Kang, Min Ji</creatorcontrib><creatorcontrib>Kim, Jae Suk</creatorcontrib><creatorcontrib>Hwang, Je Hyung</creatorcontrib><title>Intravitreal Voriconazole for Treatment of Bilateral Endogenous Candida Chorioretinitis</title><title>Case reports in ophthalmology</title><addtitle>Case Rep Ophthalmol</addtitle><description>This report describes a patient with bilateral endogenous candida chorioretinitis. The patient had a 2-day history of bilateral blurred vision. Fundus photography revealed multiple chorioretinal infiltrations in both eyes and a parafoveal hemorrhage in the left eye. After 2 days, fundus examination showed an increased number of infiltrations and hemorrhages in both eyes and worsening vitreous inflammation. A large infiltrative intraretinal lesion and a retinal hemorrhage of the left eye were discovered on optical coherence tomography. Candida albicans was diagnosed from blood culture. The bilateral candida chorioretinitis had not responded to systemic or topical antifungal medication. The chorioretinitis was refractory to intravitreal amphotericin B as well. Intravitreal voriconazole injection in both eyes and intravitreal bevacizumab injection in the left eye were performed thereafter. The chorioretinal infiltrations and hemorrhages decreased in both eyes. Intravitreal voriconazole injection was effective in the treatment of intractable candida chorioretinitis.</description><subject>Antifungal agents</subject><subject>candida chorioretinitis</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Catheters</subject><subject>Chemotherapy</subject><subject>Conflicts of interest</subject><subject>endogenous chorioretinitis</subject><subject>Fever</subject><subject>Hemorrhage</subject><subject>Internal medicine</subject><subject>Intravenous therapy</subject><subject>Medicine</subject><subject>Monoclonal antibodies</subject><subject>Oral administration</subject><subject>Patients</subject><subject>Substance abuse treatment</subject><subject>Tomography</subject><subject>voriconazole</subject><issn>1663-2699</issn><issn>1663-2699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>DOA</sourceid><recordid>eNptkc9rFDEUx4MottQevHsY6MnDan7PvIugQ9WFQj1UPYb83GadTdZMtqB_valTFgueEr7vk8_j5SH0kuA3hAh4izEWeABCn6BTIiVbUQnw9J_7CTqf523DMAM6EPEcnTAKAFIOp-j7OtWi72ItXk_dt1yizUn_zpPvQi7dTYvrzqfa5dB9iJOuvjTuMrm88Skf5m7UyUWnu_G2vc3F15hijfML9CzoafbnD-cZ-vrx8mb8vLq6_rQe31-trKBQV5ZhQwl2jltNGTMSDLeD6I3Tg9UgvDBykMGyQAZMgDtiqNW97lvGOQd2htaL12W9VfsSd7r8UllH9TfIZaN0qdFOXpEmlkL2rbPlxAAwK00wLmAYqOe2ud4trv3B7Lyz_v5rpkfSx5UUb9Um36leYEl71gQXD4KSfx78XNU2H0pq8yvKeQ-SECYb9XqhbMnzXHw4diBY3a9UHVfa2FcL-0OXjS9H8li--G95vP6yEGrvAvsDrSaoBA</recordid><startdate>20200805</startdate><enddate>20200805</enddate><creator>Sim, Ha Eun</creator><creator>Kang, Min Ji</creator><creator>Kim, Jae Suk</creator><creator>Hwang, Je Hyung</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200805</creationdate><title>Intravitreal Voriconazole for Treatment of Bilateral Endogenous Candida Chorioretinitis</title><author>Sim, Ha Eun ; Kang, Min Ji ; Kim, Jae Suk ; Hwang, Je Hyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-c30b210dd4ca233b69b4c857bda8ca95e5b686fc3f180194d1b2ca7a76fc44493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antifungal agents</topic><topic>candida chorioretinitis</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Catheters</topic><topic>Chemotherapy</topic><topic>Conflicts of interest</topic><topic>endogenous chorioretinitis</topic><topic>Fever</topic><topic>Hemorrhage</topic><topic>Internal medicine</topic><topic>Intravenous therapy</topic><topic>Medicine</topic><topic>Monoclonal antibodies</topic><topic>Oral administration</topic><topic>Patients</topic><topic>Substance abuse treatment</topic><topic>Tomography</topic><topic>voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sim, Ha Eun</creatorcontrib><creatorcontrib>Kang, Min Ji</creatorcontrib><creatorcontrib>Kim, Jae Suk</creatorcontrib><creatorcontrib>Hwang, Je Hyung</creatorcontrib><collection>Karger Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case reports in ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sim, Ha Eun</au><au>Kang, Min Ji</au><au>Kim, Jae Suk</au><au>Hwang, Je Hyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravitreal Voriconazole for Treatment of Bilateral Endogenous Candida Chorioretinitis</atitle><jtitle>Case reports in ophthalmology</jtitle><addtitle>Case Rep Ophthalmol</addtitle><date>2020-08-05</date><risdate>2020</risdate><volume>11</volume><issue>2</issue><spage>402</spage><epage>410</epage><pages>402-410</pages><issn>1663-2699</issn><eissn>1663-2699</eissn><abstract>This report describes a patient with bilateral endogenous candida chorioretinitis. The patient had a 2-day history of bilateral blurred vision. Fundus photography revealed multiple chorioretinal infiltrations in both eyes and a parafoveal hemorrhage in the left eye. After 2 days, fundus examination showed an increased number of infiltrations and hemorrhages in both eyes and worsening vitreous inflammation. A large infiltrative intraretinal lesion and a retinal hemorrhage of the left eye were discovered on optical coherence tomography. Candida albicans was diagnosed from blood culture. The bilateral candida chorioretinitis had not responded to systemic or topical antifungal medication. The chorioretinitis was refractory to intravitreal amphotericin B as well. Intravitreal voriconazole injection in both eyes and intravitreal bevacizumab injection in the left eye were performed thereafter. The chorioretinal infiltrations and hemorrhages decreased in both eyes. Intravitreal voriconazole injection was effective in the treatment of intractable candida chorioretinitis.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>32999668</pmid><doi>10.1159/000508912</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Antifungal agents candida chorioretinitis Case Report Case reports Catheters Chemotherapy Conflicts of interest endogenous chorioretinitis Fever Hemorrhage Internal medicine Intravenous therapy Medicine Monoclonal antibodies Oral administration Patients Substance abuse treatment Tomography voriconazole |
title | Intravitreal Voriconazole for Treatment of Bilateral Endogenous Candida Chorioretinitis |
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