Idiopathic Hypereosinophilic Syndrome with Multiple Organ Involvement

Idiopathic hypereosinophilic syndrome is a rare disease which is diagnosed after excluding other conditions. The syndrome is characterized by multiple organ involvement including the heart, nervous system, lungs, and gastrointestinal tract. The disease is suspected if there is peripheral blood eosin...

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Bibliographic Details
Published in:Case reports in oncology 2021-01, Vol.14 (1), p.249-255
Main Authors: Abo Shdid, Reham, Azrieh, Bahjat, Alebbi, Seham, Mansour, Shafik, Naeem, Muhammad
Format: Article
Language:English
Subjects:
Anemia
Asthma
Biopsy
Blood clots
Blood diseases
Cardiomyopathy
Cardiovascular disease
Case Report
Case reports
eosinophilia
Growth factors
Heart failure
hypereosinophilic syndrome
idiopathic hypereosinophilic syndrome
Inhibitor drugs
Kinases
Magnetic resonance imaging
Monoclonal antibodies
Morbidity
Mortality
multiple organ involvement
Myocarditis
Nervous system
Pain
Patients
Pleural effusion
Proteins
Rare diseases
Thrombocytopenia
Thrombosis
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Summary:Idiopathic hypereosinophilic syndrome is a rare disease which is diagnosed after excluding other conditions. The syndrome is characterized by multiple organ involvement including the heart, nervous system, lungs, and gastrointestinal tract. The disease is suspected if there is peripheral blood eosinophilia and no clear etiology. The main treatment is corticosteroids. Patients who do not respond to corticosteroids can be treated with imatinib, immunomodulatory agents, myelosuppressive therapy, or mepolizumab. Alemtuzumab can be considered in severe cases that are unresponsive to other therapies. In this paper, we describe a case of idiopathic hypereosinophilic syndrome with mainly cardiac system involvement and left ventricular thrombus formation which was complicated by cerebral thromboemboli while on warfarin with international normalized ratio in the therapeutic range. Our patient responded well to steroids appreciated by improvement in clinical symptoms and decrease in eosinophil count.
ISSN:1662-6575
1662-6575
DOI:10.1159/000511396