Imatinib-Resistant Gastrointestinal Stromal Tumor Presenting as a Large Abdominal Mass

Abstract Gastrointestinal stromal tumors (GISTs) are the stromal or mesenchymal neoplasms affecting the gastrointestinal tract. Although they constitute 1% of primary gastrointestinal tumors, they are the most common nonepithelial tumors involving the gastrointestinal tract. They mostly present as o...

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Bibliographic Details
Published in:Case reports in gastroenterology 2021-08, Vol.15 (2), p.736-741
Main Authors: Haider, Asim, Mehershahi, Shehriyar, Siddiqa, Ayesha, Sharma, Madhav, Patel, Harish
Format: Article
Language:English
Subjects:
Abdomen
abdominal mass
Asymptomatic
Biopsy
Case and Review
Case reports
Cysts
Endoscopy
Gastrointestinal cancer
gastrointestinal stromal tumor
imatinib
Inhibitor drugs
Medical imaging
Metastasis
Mutation
Small intestine
Stomach
Targeted cancer therapy
Tumors
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Summary:Abstract Gastrointestinal stromal tumors (GISTs) are the stromal or mesenchymal neoplasms affecting the gastrointestinal tract. Although they constitute 1% of primary gastrointestinal tumors, they are the most common nonepithelial tumors involving the gastrointestinal tract. They mostly present as overt or occult gastrointestinal bleeding. We present a case in which a 77-year-old female presented with a large abdominal mass. The origin of the mass was unclear on CT and MRI scan of the abdomen. Upper gastrointestinal endoscopic ultrasonography showed a cystic lesion in the perigastric region. A fine-needle biopsy of the lesion was performed, which was consistent with spindle type GIST. After the initial failure of imatinib therapy, the tumor was managed surgically.
ISSN:1662-0631
1662-0631
DOI:10.1159/000518122