Severe Vulvar and Perianal Crohn’s Disease: A Case Report and Review of the Literature

Association of vulvar Crohn’s disease (CD) with pyoderma gangrenosum (PG) has been described, yet due to its low prevalence, data on therapeutic management of this association are still limited. We here present a 22-year-old woman with severe vulvar and perianal CD with a major inguinal and perineal...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in dermatology 2022-03, Vol.14 (1), p.24-30
Main Authors: Le Cosquer, Guillaume, Barranca, Alexis, Lapotre, Louise, Casassa, Eline, Chaput, Benoit, Ciron, Jonathan, Buscail, Louis, Paul, Carle, Gilletta, Cyrielle
Format: Article
Language:English
Subjects:
Antibiotics
Aquaporins
Biopsy
Case and Review
Case reports
Colonoscopy
Crohn's disease
cyclosporin
Dermatology
Edema
Fistula
Granulomas
Gynecology
Immunosuppressive agents
Inflammation
Inflammatory bowel disease
infliximab
Monoclonal antibodies
Pathophysiology
Patients
Plastic surgery
pyoderma gangrenosum
Remission (Medicine)
Skin & tissue grafts
Skin diseases
Steroids
TNF inhibitors
vulvar crohn’s disease
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Association of vulvar Crohn’s disease (CD) with pyoderma gangrenosum (PG) has been described, yet due to its low prevalence, data on therapeutic management of this association are still limited. We here present a 22-year-old woman with severe vulvar and perianal CD with a major inguinal and perineal ulceration. In the hypothesis of an associated PG, oral corticosteroids were prescribed at a dose of 40 mg with limited efficacy for a duration of 3 months. Afterward, a combination treatment of cyclosporine and infliximab followed by negative pressure wound therapy and split-thickness skin graft resulted in complete healing.
ISSN:1662-6567
1662-6567
DOI:10.1159/000522033