Actinotignum schaalii Can Be an Uropathogen of “Culture-Negative” Febrile Urinary Tract Infections in Children with Urinary Tract Abnormalities

• Published in: Case reports in nephrology and dialysis 2022-09, Vol.12 (3), p.150-156
• Main Authors: Washio, Mami, Harada, Nobutaka, Nishima, Daisuke, Takemoto, Megumi
• Format: Article
• Language: English
• Subjects: 5% co2 urine culture; actinotignum schaalii; Antibiotics; Bacteria; Blood; Carbon dioxide; Case reports; Catheters; Congenital diseases; Creatinine; E coli; enhancecd quantitative urine culture; febrile uti; Fever; Gram-positive bacteria; Kidney diseases; Pathogens; Sheep; Single Case; Stains & staining; Urinary tract diseases; Urinary tract infections; Urine; Urogenital system; vesicoureteral reflux
• ISSN: 2296-9705; 2296-9705
• DOI: 10.1159/000526398

Accurate diagnosis and treatment of febrile urinary tract infections (UTI) during childhood are important for the prevention of renal parenchymal damage and functional loss, and detection of underlying diseases related to chronic kidney disease (CKD). Actinotignum schaalii (A. schaalii)-related febrile UTI in children is rare, and its incidence and risk factors remain unclear. A 3-year-old boy with a history of UTI presented with fever and vomiting. Although the culture of his urine specimen in air was negative, A. schaalii was observed in a 5% carbon dioxide (CO 2 ) culture condition, as well as an anaerobic one. A diagnosis of febrile UTI was made, and he recovered with antibiotic therapy. He was found to have CKD associated with vesicoureteral reflux (VUR) after further investigations. A. schaalii is one of the causative agents of febrile UTI in children with urinary tract abnormalities. Although the culture in the air could show negative results, urine culture in 5% CO 2 and anaerobic conditions is useful for diagnosis. Our case is the youngest and the first known case of A. schaalii-related febrile UTI associated with VUR in children.