Medical Cannabis Alleviates Chronic Neuropathic Pain Effectively and Sustainably without Severe Adverse Effect: A Retrospective Study on 99 Cases

Abstract Introduction: Medical cannabis may provide a treatment option for chronic neuropathic pain. However, empirical disease-specific data are scarce. Methods: This is a retrospective observational study including 99 patients with chronic neuropathic pain. These patients received medical cannabis...

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Bibliographic Details
Published in:Medical cannabis and cannabinoids 2023-01, Vol.6 (1), p.89-96
Main Authors: Kluwe, Lan, Scholze, Christian, Schmidberg, Lisa Marie, Wichmann, Julian Lukas, Gemkov, Mihail, Keller, Martin Julian, Farschtschi, Said C.
Format: Article
Language:English
Subjects:
cannabinoids
medical cannabis
neuropathic pain
Preclinical Science and Clinical Studies
Preclinical Science and Clinical Studies – Research Article
side effect
sleep disturbance
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Summary:Abstract Introduction: Medical cannabis may provide a treatment option for chronic neuropathic pain. However, empirical disease-specific data are scarce. Methods: This is a retrospective observational study including 99 patients with chronic neuropathic pain. These patients received medical cannabis by means of inhaling dried flowers with tetrahydrocannabinol content of 6) decreased from 96% to 16% (p < 0.001). Sleep disturbance was significantly improved with the median of the scores decreased from 8.0 to 2.0 (p < 0.001). These improvements were sustained over a period of up to 6 months. There were no severe adverse events reported. Mild side effects reported were dryness in mucous tissue (5.4%), fatigue (4.8%), and increased appetite (2.7%). Therapy tolerance was reported in 91% of the interviews. Conclusion: Medical cannabis is safe and highly effective for treating neuropathic pain and concomitant sleep disturbance.
ISSN:2504-3889
2504-3889
DOI:10.1159/000531667