Primary Splenic Diffuse Large B-Cell Lymphoma: A Case Report and Literature Review of a Rare Condition

Abstract Introduction: Primary splenic lymphoma is a rare lymphoproliferative disorder that involves the spleen, exhibits diverse clinical presentations, and lacks a clear consensus in terms of management strategies. Case Presentation: We present the case of a 52-year-old patient with a complex medi...

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Bibliographic Details
Published in:Case reports in oncology 2024-01, Vol.17 (1), p.447-453
Main Authors: Seijari, Mohammed Najdat, Kaspo, Samer, Alshurafa, Awni, Elfaieg, Amro, Elkourashy, Sarah A.
Format: Article
Language:English
Subjects:
Abdomen
Antibodies
Bone marrow
Case Report
Case reports
Chemotherapy
Diabetes
diffuse large b-cell lymphoma of the spleen
Hepatitis C
Hypertension
Lymphatic system
Lymphocytes
Lymphoma
malignancy
Metabolism
Metastasis
Morphology
non-hodgkin’s lymphoma of the spleen
Patients
primary splenic lymphoma
Radiation therapy
Remission (Medicine)
Spleen
splenomegaly
Tumors
Ultrasonic imaging
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Summary:Abstract Introduction: Primary splenic lymphoma is a rare lymphoproliferative disorder that involves the spleen, exhibits diverse clinical presentations, and lacks a clear consensus in terms of management strategies. Case Presentation: We present the case of a 52-year-old patient with a complex medical history marked by multiple chronic medical conditions. The patient was diagnosed with primary splenic lymphoma, specifically the diffuse large B-cell subtype. Treatment for our patient involved a shortened course of chemotherapy (4 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone [R-CHOP] followed by two doses of rituximab) due to issues related to compliance and treatment-related complications. This was followed by consolidative radiotherapy without resorting to splenectomy. Conclusion: Remarkably, despite using a shortened course of R-CHOP, the patient achieved complete resolution, and a positron emission tomography scan conducted at the end of the 6-month posttreatment period confirmed sustained complete remission.
ISSN:1662-6575
1662-6575
DOI:10.1159/000537780