Role of Cancer Side Population Stem Cells in Ovarian Cancer Angiogenesis

Abstract Ovarian cancer is one of the most common gynecologic malignancies. Recurrence and metastasis often occur after treatment, and it has the highest mortality rate of all gynecological tumors. Cancer stem cells (CSCs) are a small population of cells with the ability of self-renewal, multidirect...

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Bibliographic Details
Published in:Medical Principles and Practice 2024-10, Vol.33 (5), p.403-413
Main Authors: Pan, Yue, Yang, XueFen, Chen, Miaojuan, Shi, Kun, Lyu, Yuan, Meeson, Annette P., Lash, Gendie E.
Format: Article
Language:English
Subjects:
Biomarkers
Breast cancer
Mortality
Ovarian cancer
Review
Womens health
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Summary:Abstract Ovarian cancer is one of the most common gynecologic malignancies. Recurrence and metastasis often occur after treatment, and it has the highest mortality rate of all gynecological tumors. Cancer stem cells (CSCs) are a small population of cells with the ability of self-renewal, multidirectional differentiation, and infinite proliferation. They have been shown to play an important role in tumor growth, metastasis, drug resistance, and angiogenesis. Ovarian cancer side population (SP) cells, a type of CSC, have been shown to play roles in tumor formation, colony formation, xenograft tumor formation, ascites formation, and tumor metastasis. The rapid progression of tumor angiogenesis is necessary for tumor growth; however, many of the mechanisms driving this process are unclear as is the contribution of CSCs. The aim of this review was to document the current state of knowledge of the molecular mechanism of ovarian cancer stem cells (OCSCs) in regulating tumor angiogenesis.
ISSN:1011-7571
1423-0151
1423-0151
DOI:10.1159/000539642