BMB reports : NCAM as a cystogenesis marker gene of PKD2 overexpression

ADPKD (Autosomal Dominant Polycystic Kidney Disease) is characterized by the progressive expansion of multiple cystic lesions in the kidneys. ADPKD is caused by mutations in Ed-pl. consider PKD1 and PKD2. Recently a relation between c-myc and the pathogenesis of ADPKD was reported. In addition, c-My...

Full description

Saved in:
Bibliographic Details
Published in:BMB reports 2008-08, Vol.41 (8), p.593
Main Authors: Kyung Hyun Yoo, Tae Young Lee, Moon Hee Yang, Eun Young Park, Yeon Joo Yook, Hyo Soo Lee, Jong Hoon Park
Format: Article
Language:Korean
Subjects:
c-Myc
cDNA microarray
Cystogenesis
NACM
PKD2 findings indicate that NCAM plays an important role during cyst formation by PKD2 overexpression
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ADPKD (Autosomal Dominant Polycystic Kidney Disease) is characterized by the progressive expansion of multiple cystic lesions in the kidneys. ADPKD is caused by mutations in Ed-pl. consider PKD1 and PKD2. Recently a relation between c-myc and the pathogenesis of ADPKD was reported. In addition, c-Myc is a downstream effector of PKD1. To identify the gene regulated by PKD2 and c-Myc, we performed gene expression profiling in PKD2 and c-Myc overexpressing cells using a human 8K cDNA microarray. NCAM (neuronal cell adhesion molecule) levels were significantly reduced in PKD2 overexpressing systems in vitro and in vivo. These results suggest that NCAM is an important molecule in the cystogenesis induced by PKD2 overexpession.
ISSN:1976-6696