Experimental Research Article : Rocuronium-induced neuromuscular block after Long pretreatment of clonidine in rabbits

Background: Clonidine, an α-2 adrenergic agonist, is used in the perioperative period and in intensive care for the management of hypertension. The in vivo and in vitro effects of clonidine on the actions of nondepolarizing neuromuscular blocking drugs are conflicting. We evaluated the potency and t...

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Bibliographic Details
Published in:Korean journal of anesthesiology 2010-09, Vol.59 (3), p.190
Main Authors: Sung Wook Yoon, Hee Jong Lee, Kyo Sang Kim, Min Seok Koo, Nam Yun Kim
Format: Article
Language:Korean
Subjects:
Clonidine
Pharmacodynamics
Rabbits
Rocuronium
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Summary:Background: Clonidine, an α-2 adrenergic agonist, is used in the perioperative period and in intensive care for the management of hypertension. The in vivo and in vitro effects of clonidine on the actions of nondepolarizing neuromuscular blocking drugs are conflicting. We evaluated the potency and time course of rocuronium-induced neuromuscular block after prolonged pretreatment with clonidine in rabbits. Methods: Sixty rabbits were randomly assigned to three groups; control (C) group: normal saline 0.1 ml/kg daily subcutaneous for 6 weeks; S3 group: clonidine 4 μg/kg daily subcutaneous for 3 weeks; S6 group: clonidine 4 μg/kg daily subcutaneous for 6 weeks. The dose-response relations of rocuronium were tested in 30 rabbits (10 from each of the three groups) during ketamine-thiopental anesthesia, while the time course of rocuronium 0.6 mg/kg was examined in 10 rabbits each from the three groups. Results: There was no difference in mean arterial pressure and pulse rate among the experimental groups. The calculated ED50 for rocuronium decreased significantly from 64.1 μg/kg (C group) to 50.3 μg/kg (S3 group) and 47.8 μg/kg (S6 group) (P
ISSN:2005-6419