Mini Review : Chemical kinomics: a powerful strategy for target deconvolution

Kinomics is an emerging and promising approach for deciphering kinomes. Chemical kinomics is a discipline of chemical genomics that is also referred to as "chemogenomics", which is derived from chemistry and biology. Chemical kinomics has become a powerful approach to decipher complicated...

Full description

Saved in:
Bibliographic Details
Published in:BMB reports 2010-11, Vol.43 (11), p.711
Main Authors: Do Hee Kim, Tae Bo Sim
Format: Article
Language:Korean
Subjects:
Chemical kinomics
Kinase inhibitor
Protein kinase
Target identification
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kinomics is an emerging and promising approach for deciphering kinomes. Chemical kinomics is a discipline of chemical genomics that is also referred to as "chemogenomics", which is derived from chemistry and biology. Chemical kinomics has become a powerful approach to decipher complicated phosphorylation-based cellular signaling networks with the aid of small molecules that modulate kinase functions. Moreover, chemical kinomics has played a pivotal role in the field of kinase drug discovery as it enables identification of new molecular targets of small molecule kinase modulators and/or exploitation of novel functions of known kinases and has also provided novel chemical entities as hit/lead compounds. In this short review, contemporary chemical kinomics technologies such as activity-based protein profiling, T7 kinase-tagged phages, kinobeads, three-hybrid systems, fluorescent-tagged kinase binding assays, and chemical genomic profiling are discussed along with a novel allosteric Bcr-Abl kinase inhibitor (GNF-2/GNF-5) as a successful application of chemical kinomics approaches. [BMB reports 2010; 43(11): 711-719]
ISSN:1976-6696