The effects of hydrogen sulfide under sevoflurane administration against ischemia and reperfusion injury in isolated rat heart

Background: Hydrogen sulfide (H2S) produces a protective effect against myocardial ischemia and reperfusion injury. Sevoflurane, which is used for anesthesia in cardiac problem patients, also has a protective effect. This study is designed to reveal the effects of H2S under sevoflurane using rat hea...

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Bibliographic Details
Published in:Korean journal of anesthesiology 2012-05, Vol.62 (5), p.461
Main Authors: Dong Kyu Lee, Nan Suk Kim, Sang Ho Lim
Format: Article
Language:Korean
Subjects:
Heart
Hydrogen sulfide
In vitro
Ischemia
Reperfusion injury
Sevoflurane
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Summary:Background: Hydrogen sulfide (H2S) produces a protective effect against myocardial ischemia and reperfusion injury. Sevoflurane, which is used for anesthesia in cardiac problem patients, also has a protective effect. This study is designed to reveal the effects of H2S under sevoflurane using rat hearts. Methods: The hearts were Langendorff-perfused, subjected to 30 minutes ischemia and 60 minutes reperfusion. Group I was a control group. The other groups were pretreated for 15 minutes before ischemia as follows: 1.6% sevoflurane for group S; 18.5 μM H2S S for group H; and 1.6 % sevoflurane and 18.5 μM H2S simultaneously for group HS. Hemodynamics and the infarct size were measured. Results: Group HS presented depressed hemodynamics during pretreatment. LV function in group HS achieved better recovery than group I after reperfusion. The infarct size of groups S, H and HS was smaller than group I, while there were no differences between groups S, H and HS. Conclusions: Exogenous H2S did not enhance the preconditioning effects of sevoflurane. Rather, the results suggest that H2S under sevoflurane might depress hemodynamics. (Korean J Anesthesiol 2012; 62: 461-467)
ISSN:2005-6419