Case Reports : A fatal case of hepatitis B virus (HBV) reactivation during Long-term, very-Low-dose steroid treatment in an inactive HBV carrier

Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We...

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Bibliographic Details
Published in:Clinical and molecular hepatology 2012-06, Vol.18 (2), p.225
Main Authors: Joong Ho Bae, Joo Hyun Sohn, Hye Soon Lee, Hye Sun Park, Yil Sik Hyun, Tae Yeob Kim, Chang Soo Eun, Yong Cheol Jeon, Dong Soo Han
Format: Article
Language:Korean
Subjects:
Hepatitis B virus
Liver failure
Steroids
Virus activation
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Summary:Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV. (Clin Mol Hepatol 2012;18:225-228)
ISSN:2287-2728