Genetic variants and signatures of selective sweep of Hanwoo population Korean native cattle

Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 17681...

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Bibliographic Details
Published in:BMB reports 2013-07, Vol.46 (7), p.346
Main Authors: Tae Heon Lee, Seoae Cho, Seok Seo Kang, Jong Soo Chang, Hee Bal Kim, Du Hak Yoon
Format: Article
Language:Korean
Subjects:
Adaptation
Genetic variants
Hanwoo
Korean native cattle
Selective sweep
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Summary:Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445 CNVs. The SNPs, INDELs, and CNVs were similarly distributed throughout the genome, and highly variable regions were shown to contain the BoLA family and GPR180, which are related to adaptive immunity. We also identified the domestication footprints of the Hanwoo population by searching for selective sweep signatures, which revealed the RCN2 gene related to BPV resistance. The results of this study may contribute to genetic improvement of the Hanwoo population in Korea.
ISSN:1976-6696