Surgical impact on serum anti-Mullerian hormone in women with benign ovarian cyst ; A prospective study

Objective The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences...

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Published in:Obstetrics & gynecology science 2014-03, Vol.57 (2), p.121
Main Authors: Won Kyu Jang, Su Yeon Lim, Joon Cheol Park, Kyung Ryul Lee, An Na Lee, Jeong Ho Rhee
Format: Article
Language:Korean
Subjects:
Anti-Mullerian hormone
Benign ovarian mass
Endometrioma
Laparoscopic cystectomy
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Summary:Objective The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences in ovarian reserve impairment between endometrioma cystectomy and non-endometrioma cystectomy were investigated. Methods In this prospective study, 22 patients of reproductive age (range, 18-35 years) with benign ovarian masses were enrolled to undergo laparoscopic cystectomy. Of whom 12 had endometriomas and 10 had non-endometriomas. On early follicular phase (day 3) of the cycle preceding the operation and three months after the laparoscopic cystectomy, serum levels of FSH, E2 and AMH, AFC and ovarian volumes were measured in all patients. Data were analyzed with Mann-Whitney U-test and Wilcoxon rank test using SPSS ver. 12.0 for statistic analysis. Results Median level of serum AMH was significantly decreased from 5.48 ng/mL (interquartile range [IQR], 2.80-7.47) before cystectomy to 2.56 ng/mL (IQR, 1.74-4.32) 3 months postoperation ( P
ISSN:2287-8572