Surgical impact on serum anti-Mullerian hormone in women with benign ovarian cyst ; A prospective study

Objective The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences...

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Published in:Obstetrics & gynecology science 2014-03, Vol.57 (2), p.121
Main Authors: Won Kyu Jang, Su Yeon Lim, Joon Cheol Park, Kyung Ryul Lee, An Na Lee, Jeong Ho Rhee
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Language:Korean
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Anti-Mullerian hormone
Benign ovarian mass
Endometrioma
Laparoscopic cystectomy
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container_issue 2
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container_title Obstetrics & gynecology science
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creator Won Kyu Jang
Su Yeon Lim
Joon Cheol Park
Kyung Ryul Lee
An Na Lee
Jeong Ho Rhee
description Objective The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences in ovarian reserve impairment between endometrioma cystectomy and non-endometrioma cystectomy were investigated. Methods In this prospective study, 22 patients of reproductive age (range, 18-35 years) with benign ovarian masses were enrolled to undergo laparoscopic cystectomy. Of whom 12 had endometriomas and 10 had non-endometriomas. On early follicular phase (day 3) of the cycle preceding the operation and three months after the laparoscopic cystectomy, serum levels of FSH, E2 and AMH, AFC and ovarian volumes were measured in all patients. Data were analyzed with Mann-Whitney U-test and Wilcoxon rank test using SPSS ver. 12.0 for statistic analysis. Results Median level of serum AMH was significantly decreased from 5.48 ng/mL (interquartile range [IQR], 2.80-7.47) before cystectomy to 2.56 ng/mL (IQR, 1.74-4.32) 3 months postoperation ( P
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In addition, the differences in ovarian reserve impairment between endometrioma cystectomy and non-endometrioma cystectomy were investigated. Methods In this prospective study, 22 patients of reproductive age (range, 18-35 years) with benign ovarian masses were enrolled to undergo laparoscopic cystectomy. Of whom 12 had endometriomas and 10 had non-endometriomas. On early follicular phase (day 3) of the cycle preceding the operation and three months after the laparoscopic cystectomy, serum levels of FSH, E2 and AMH, AFC and ovarian volumes were measured in all patients. Data were analyzed with Mann-Whitney U-test and Wilcoxon rank test using SPSS ver. 12.0 for statistic analysis. Results Median level of serum AMH was significantly decreased from 5.48 ng/mL (interquartile range [IQR], 2.80-7.47) before cystectomy to 2.56 ng/mL (IQR, 1.74-4.32) 3 months postoperation ( P&lt;0.05). On the other hand, no significant differences in FSH, E2, AFC and ovarian volumes were found between the preoperative and three months postoperative levels. In a subgroup analysis of the pathologic type of the ovarian cyst, postoperative serum AMH levels were significantly decreased in the endometrioma group, but not in the non-endometrioma group. Conclusion Serum AMH levels were significantly decreased after laparoscopic cystectomy without any changes of other ovarian reserve tests.</description><identifier>ISSN: 2287-8572</identifier><language>kor</language><publisher>대한산부인과학회</publisher><subject>Anti-Mullerian hormone ; Benign ovarian mass ; Endometrioma ; Laparoscopic cystectomy</subject><ispartof>Obstetrics &amp; gynecology science, 2014-03, Vol.57 (2), p.121</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Won Kyu Jang</creatorcontrib><creatorcontrib>Su Yeon Lim</creatorcontrib><creatorcontrib>Joon Cheol Park</creatorcontrib><creatorcontrib>Kyung Ryul Lee</creatorcontrib><creatorcontrib>An Na Lee</creatorcontrib><creatorcontrib>Jeong Ho Rhee</creatorcontrib><title>Surgical impact on serum anti-Mullerian hormone in women with benign ovarian cyst ; A prospective study</title><title>Obstetrics &amp; gynecology science</title><addtitle>Obstetrics &amp; Gynecology Science</addtitle><description>Objective The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences in ovarian reserve impairment between endometrioma cystectomy and non-endometrioma cystectomy were investigated. Methods In this prospective study, 22 patients of reproductive age (range, 18-35 years) with benign ovarian masses were enrolled to undergo laparoscopic cystectomy. Of whom 12 had endometriomas and 10 had non-endometriomas. On early follicular phase (day 3) of the cycle preceding the operation and three months after the laparoscopic cystectomy, serum levels of FSH, E2 and AMH, AFC and ovarian volumes were measured in all patients. Data were analyzed with Mann-Whitney U-test and Wilcoxon rank test using SPSS ver. 12.0 for statistic analysis. Results Median level of serum AMH was significantly decreased from 5.48 ng/mL (interquartile range [IQR], 2.80-7.47) before cystectomy to 2.56 ng/mL (IQR, 1.74-4.32) 3 months postoperation ( P&lt;0.05). On the other hand, no significant differences in FSH, E2, AFC and ovarian volumes were found between the preoperative and three months postoperative levels. In a subgroup analysis of the pathologic type of the ovarian cyst, postoperative serum AMH levels were significantly decreased in the endometrioma group, but not in the non-endometrioma group. Conclusion Serum AMH levels were significantly decreased after laparoscopic cystectomy without any changes of other ovarian reserve tests.</description><subject>Anti-Mullerian hormone</subject><subject>Benign ovarian mass</subject><subject>Endometrioma</subject><subject>Laparoscopic cystectomy</subject><issn>2287-8572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9irEOgjAURTtoIlG-wOX9AAkUCU2cjNG4OOlOaq3wlLakr2D4e4lx9g7nDOfOWMS5KBNRlHzBYqJnOk0UmRCbiNWX3teoZAtoOqkCOAukfW9A2oDJuW9b7VFaaJw3zmpAC29n9EQMDdy0xdqCG-T3pEYKsIUddN5Rp1XAQQOF_j6u2PwhW9Lxz0u2Ph6u-1PyQqKq82ikH6ucZznP0_x__QC23kHr</recordid><startdate>20140330</startdate><enddate>20140330</enddate><creator>Won Kyu Jang</creator><creator>Su Yeon Lim</creator><creator>Joon Cheol Park</creator><creator>Kyung Ryul Lee</creator><creator>An Na Lee</creator><creator>Jeong Ho Rhee</creator><general>대한산부인과학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>20140330</creationdate><title>Surgical impact on serum anti-Mullerian hormone in women with benign ovarian cyst ; A prospective study</title><author>Won Kyu Jang ; Su Yeon Lim ; Joon Cheol Park ; Kyung Ryul Lee ; An Na Lee ; Jeong Ho Rhee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_32132303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2014</creationdate><topic>Anti-Mullerian hormone</topic><topic>Benign ovarian mass</topic><topic>Endometrioma</topic><topic>Laparoscopic cystectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Won Kyu Jang</creatorcontrib><creatorcontrib>Su Yeon Lim</creatorcontrib><creatorcontrib>Joon Cheol Park</creatorcontrib><creatorcontrib>Kyung Ryul Lee</creatorcontrib><creatorcontrib>An Na Lee</creatorcontrib><creatorcontrib>Jeong Ho Rhee</creatorcontrib><collection>KISS (한국학술정보)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>Obstetrics &amp; gynecology science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Won Kyu Jang</au><au>Su Yeon Lim</au><au>Joon Cheol Park</au><au>Kyung Ryul Lee</au><au>An Na Lee</au><au>Jeong Ho Rhee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical impact on serum anti-Mullerian hormone in women with benign ovarian cyst ; A prospective study</atitle><jtitle>Obstetrics &amp; gynecology science</jtitle><addtitle>Obstetrics &amp; Gynecology Science</addtitle><date>2014-03-30</date><risdate>2014</risdate><volume>57</volume><issue>2</issue><spage>121</spage><pages>121-</pages><issn>2287-8572</issn><abstract>Objective The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences in ovarian reserve impairment between endometrioma cystectomy and non-endometrioma cystectomy were investigated. Methods In this prospective study, 22 patients of reproductive age (range, 18-35 years) with benign ovarian masses were enrolled to undergo laparoscopic cystectomy. Of whom 12 had endometriomas and 10 had non-endometriomas. On early follicular phase (day 3) of the cycle preceding the operation and three months after the laparoscopic cystectomy, serum levels of FSH, E2 and AMH, AFC and ovarian volumes were measured in all patients. Data were analyzed with Mann-Whitney U-test and Wilcoxon rank test using SPSS ver. 12.0 for statistic analysis. Results Median level of serum AMH was significantly decreased from 5.48 ng/mL (interquartile range [IQR], 2.80-7.47) before cystectomy to 2.56 ng/mL (IQR, 1.74-4.32) 3 months postoperation ( P&lt;0.05). On the other hand, no significant differences in FSH, E2, AFC and ovarian volumes were found between the preoperative and three months postoperative levels. In a subgroup analysis of the pathologic type of the ovarian cyst, postoperative serum AMH levels were significantly decreased in the endometrioma group, but not in the non-endometrioma group. Conclusion Serum AMH levels were significantly decreased after laparoscopic cystectomy without any changes of other ovarian reserve tests.</abstract><pub>대한산부인과학회</pub><tpages>7</tpages></addata></record>
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subjects Anti-Mullerian hormone
Benign ovarian mass
Endometrioma
Laparoscopic cystectomy
title Surgical impact on serum anti-Mullerian hormone in women with benign ovarian cyst ; A prospective study
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