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Hepatitis B surface antigen levels at 6 months after treatment can predict the efficacy of lamivudine- adefovir combination therapy in patients with lamivudine- resistant chronic hepatitis B
Background/Aims: Quantitation of hepatitis B surface antigen (HBsAg) is an increasingly popular method to determine the treatment response in chronic hepatitis B (CHB) patients. The clinical value of HBsAg level measurement during rescue therapy for lamivudine (LMV)-resistant CHB patients have not b...
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Published in: | Clinical and molecular hepatology 2014-09, Vol.20 (3), p.274 |
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Main Authors: | , , , , |
Format: | Article |
Language: | Korean |
Subjects: | |
Online Access: | Get full text |
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Summary: | Background/Aims: Quantitation of hepatitis B surface antigen (HBsAg) is an increasingly popular method to determine the treatment response in chronic hepatitis B (CHB) patients. The clinical value of HBsAg level measurement during rescue therapy for lamivudine (LMV)-resistant CHB patients have not been evaluated to date. Therefore, this study investigated the correlation between HBsAg level and treatment response in LMV- resistant CHB patients treated with adefovir (ADV) add-on therapy. Methods: LMV-resistant CHB patients treated with LMV-ADV combination therapy for over 2 years were included. HBsAg levels were measured at 6 month intervals until 1 year, and annually thereafter. Treatment response was assessed by determining the virological response (VR, undetectable HBV DNA levels) during treatment. Results: Fifty patients were included, of which 40 showed a VR. HBsAg levels were not different significantly at baseline (4.0 vs. 3.6 Log10 IU/mL, P=0.072). However, the HBsAg level decreased after 6 months of treatment in patients with a VR and became different significantly between the groups thereafter (3.9 vs. 3.3 at 6 months, P=0.002; 3.8 vs. 3.2 at 1 year, P=0.004; 3.9 vs. 3.2 at 2 years, P=0.008; 3.7 vs. 3.1 at 3 years, P=0.020). Conclusions: The HBsAg level at 6 months after treatment can help predict treatment response. (Clin Mol Hepatol 2014;20:274-282) |
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ISSN: | 2287-2728 |