Case Report : Severe neurologic manifestations in acute intermittent porphyria developed after spine surgery under general anesthesia -a case report

Porphyrias are inherited metabolic disorders resulting from a specific enzyme defect in the heme biosynthetic pathway. Porphyrias are induced by various precipitants. Clinical features include abdominal pain, neurologic manifestations, autonomic neuropathy, and mental disturbance. Diagnosis may be d...

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Bibliographic Details
Published in:Korean journal of anesthesiology 2014-09, Vol.67 (3), p.217
Main Authors: Eun Young Park, Yi Seul Kim, Kyung Jee Lim, Hye Kyoung Lee, Soo Kyung Lee, Hyun Choi, Mae Hwa Kang
Format: Article
Language:Korean
Subjects:
Delayed emergence from anesthesia
General anesthesia
Guillain-Barre Syndrome
Porphyrias
Wernicke encephalopathy
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Summary:Porphyrias are inherited metabolic disorders resulting from a specific enzyme defect in the heme biosynthetic pathway. Porphyrias are induced by various precipitants. Clinical features include abdominal pain, neurologic manifestations, autonomic neuropathy, and mental disturbance. Diagnosis may be delayed because of variable symptoms that mimic other diseases and because of the rarity of of porphyrias. Although most patients with known porphyria can complete anesthesia and surgery safely, undiagnosed porphyric patients are in danger of porphyric crisis due to inadvertent exposure to precipitating drugs and environment. We report a case of a patient who experienced delayed emergence with neurological disturbance after general anesthesia, ultimately diagnosed as acute intermittent porphyria.
ISSN:2005-6419