Disease Progression in Chronic Hepatitis B Patients under Long-Term Antiviral Therapy

Background/Aims: We investigated factors associated with the disease progression and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients during long-term oral nucleos(t)ide analog (NA) therapy. Methods: This retrospective study included 524 naive CHB patients who rece...

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Bibliographic Details
Published in:Gut and liver 2015-05, Vol.9 (3), p.395
Main Authors: Jin Chang Moon, Seong Hun Kim, In Hee Kim, Chang Hun Lee, Sang Wook Kim, Seung Ok Lee, Soo Teik Lee, Dae Ghon Kim
Format: Article
Language:Korean
Subjects:
Antiviral therapy
Carcinoma
Disease
hepatocellular
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Summary:Background/Aims: We investigated factors associated with the disease progression and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients during long-term oral nucleos(t)ide analog (NA) therapy. Methods: This retrospective study included 524 naive CHB patients who received oral NA therapy for more than 48 weeks between January 2003 and December 2007. The primary outcome was 5-year cumulative probability of disease progression and HCC development. Disease progression was defined as cirrhosis development, cirrhotic complications, HCC or liver-related mortality. Results: For the 524 patients, the cumulative probabilities of disease progression and HCC development at 1, 2, 3, 4 and 5 years were 1.1%, 6.3%, 9.0%, 11.6%, and 16.2% and 0.2%, 1.8%, 3.6%, 5.8%, and 9.3%, respectively. In multivariate analysis, age >50 years (hazard ratio [HR], 1.05) and cirrhosis (HR, 2.95) were significant factors for disease progression. Similarly, age >50 years (HR, 1.05), family history of HCC (HR, 5.48), and cirrhosis (HR, 17.16) were significant factors for HCC development. Importantly, longer duration (>12 months) of maintained virological response (
ISSN:1976-2283