Case Reports : Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report

Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33 yearold male patient who was admitted with Stevens-Johnson syndrome a...

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Bibliographic Details
Published in:Clinical and molecular hepatology 2015-06, Vol.21 (2), p.180
Main Authors: Sung Gyu Im, Sun Hong Yoo, Young Min Park, Sang Jin Lee, Sun Kyung Jang, Dong Ok Jeon, Hyo Jin Cho, Mi Jung Oh
Format: Article
Language:Korean
Subjects:
Hepatotoxicity
Hypersensitivity
Lamotrigine
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Summary:Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33 yearold male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine. (Clin Mol Hepatol 2015;21:180-182)
ISSN:2287-2728