Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study

Background/Aims: We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE). Methods: A multicenter retrospective study was conducted using data collected from the CE nationwid...

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Published in:Gut and liver 2015-11, Vol.9 (6), p.727
Main Authors: Ki-Nam Shim, Eun Mi Song, Yoon Tae Jeen, Jin-Oh Kim, Seong Ran Jeon, Dong Kyung Chang, Hyun Joo Song, Yun Jeong Lim, Jin Soo Kim, Byong Duk Ye, Cheol Hee Park, Seong Woo Jeon, Jae Hee Cheon, Kwang Jae Lee, Ji Hyun Kim, Byung Ik Jang, Jeong Seop Moon, Hoon Jae Chun, Myung-Gyu Choi
Format: Article
Language:Korean
Subjects:
Anti-inflammatory agents
Capsule endoscopy
non-steroidal
Outcome
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Summary:Background/Aims: We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE). Methods: A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002. Results: A total of 140 patients (87 males; mean age, 60.6±14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9±19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence. Conclusions: These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important. (Gut Liver 2015;9:727-733)
ISSN:1976-2283