Kojic Acid Peptide: A New Compound with Anti-Tyrosinase Potential

Background: Kojic acid was used for decades in the cosmetic industry as an antimelanogenic agent. However, there are two major drawbacks of Kojic acid, one is cytotoxicity and second are instability on storage. These limitations led the scientist to synthesize the active Kojic acid peptides. Objecti...

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Bibliographic Details
Published in:Annals of dermatology 2016-10, Vol.28 (5), p.555
Main Authors: Birendra Kumar Singh, Seok Hoon Park, Hyang Bok Lee, Young Aae Goo, Hyoung Shik Kim, Seung Hee Cho, Jeong Hun Lee, Ghe Whan Ahn, Jin Pyo Kim, Su Myoung Kang, Eun Ki Kim
Format: Article
Language:Korean
Subjects:
Hypopgmentation
Kojic acid
Melanin
Peptides
Tyrosinase
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Summary:Background: Kojic acid was used for decades in the cosmetic industry as an antimelanogenic agent. However, there are two major drawbacks of Kojic acid, one is cytotoxicity and second are instability on storage. These limitations led the scientist to synthesize the active Kojic acid peptides. Objective: In the present study, we synthesize and investigate the effect of five Kojic acid peptides to overcome the limitation of Kojic acid. Methods: The peptide was analyzed and purified by high-performance liquid chromatography and matrix-assisted laser desorption ionization time of flight mass spectroscopy. Further, the tyrosinase activities of the Kojic acid and Kojic acid peptides were compared. The toxicity was measured and the melanin content is recorded in B16F10 mouse melanoma cells. Results: Maximum tyrosinase activity was measured by Kojic acid peptides. Therefore, Kojic acid peptides were subjected to melanin assay and cytotoxicity assay and finally the stability of the Kojic acid peptide was measured. Conclusion: It was observed that this newly synthesized Kojic acid peptide is stable and potent to inhibit the tyrosinase activity and melanin content of B16F10 mouse melanoma cells without exhibiting cell toxicity. Together, these preliminary results suggest that a further exploration is being needed to establish Kojic acid peptide as antimelanogenic agent. (Ann Dermatol 28(5) 555∼561, 2016)
ISSN:1013-9087
2005-3894