Efficacy of Taurolidine Irrigation in Primary Total Knee Arthroplasty

Purpose: Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis. The aim of this study was to evaluate the efficacy of taurolidine irrigation in primary total knee arthroplasty (TKA). Materials and Methods: All patients who underwent TKA at our institute...

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Bibliographic Details
Published in:Knee surgery & related research 2018-06, Vol.30 (2), p.142
Main Authors: Young Ha Woo, Ju Seon Jeong, Ok Geol Kim, In Seung Lee
Format: Article
Language:Korean
Subjects:
Arthroplasty
C-reactive protein
Infection
Knee
Taurolidine
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Summary:Purpose: Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis. The aim of this study was to evaluate the efficacy of taurolidine irrigation in primary total knee arthroplasty (TKA). Materials and Methods: All patients who underwent TKA at our institute from January 2015 to March 2017 were eligible. There were 300 patients in the taurolidine irrigation group and 300 patients in the control group. The patients in the taurolidine irrigation group were irrigated after implantation with a mix of 250 mL of taurolidine and 750 mL of normal saline. The patients in the control group were not irrigated after implantation. We compared postoperative C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and infection rate between groups. Results: The taurolidine irrigation group had a significantly lower CRP (5.39 mg/dL vs. 7.55 mg/dL; p
ISSN:2234-0726