Low-Normal Free Thyroxine Levels in Euthyroid Male Are Associated with Prediabetes

Abnormal thyroid function is associated with impaired glucose homeostasis. This study aimed to determine whether free thyroxine (FT4) influences the prevalence of prediabetes in euthyroid subjects using a cross-sectional survey derived from the Korea National Health and Nutrition Examination Survey,...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes & metabolism journal 2019-10, Vol.43 (5), p.718
Main Authors: Sung Woo Kim, Jae-han Jeon, Jun Sung Moon, Eon Ju Jeon, Mi-kyung Kim, In-kyu Lee, Jung Beom Seo, Keun-gyu Park
Format: Article
Language:Korean
Subjects:
Blood glucose
Glycated hemoglobin A
Prediabetic state
Thyroxine
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abnormal thyroid function is associated with impaired glucose homeostasis. This study aimed to determine whether free thyroxine (FT4) influences the prevalence of prediabetes in euthyroid subjects using a cross-sectional survey derived from the Korea National Health and Nutrition Examination Survey, conducted between 2013 and 2015. We studied 2,399 male participants of >20 years of age who were euthyroid and non-diabetic. Prediabetic participants had lower FT4 concentrations than those without prediabetes, but their thyrotropin concentrations were similar. We stratified the population into tertiles according to FT4 concentration. After adjusting for multiple confounding factors, glycosylated hemoglobin (HbA1c) levels significantly decreased with increasing FT4 tertile, whereas fasting plasma glucose (FPG) levels were not associated with FT4 tertiles (HbA1c, P
ISSN:2233-6079