Cordycepin from Medicinal Fungi Cordyceps militaris Mitigates Inflammaging-Associated Testicular Damage via Regulating NF-jB/MAPKs Signaling in Naturally Aged Rats

Inflammaging in male reproductive organs covers a wide variety of problems, including sexual dysfunction and infertility. In this study, the beneficial effects of cordycepin (COR), isolated from potential medicinal fungi Cordyceps militaris, in aging-associated testicular inflammation and serum bioc...

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Bibliographic Details
Published in:Mycobiology 2022-02, Vol.50 (1), p.86
Main Authors: Spandana Rajendra Kopalli, Kyu-min Cha, Jae Youl Cho, Si-kwan Kim, Sushruta Koppula
Format: Article
Language:Korean
Subjects:
Cordyceps militaris
cytokines
inflammaging
interleukin
MAPKs
testicular damage
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Summary:Inflammaging in male reproductive organs covers a wide variety of problems, including sexual dysfunction and infertility. In this study, the beneficial effects of cordycepin (COR), isolated from potential medicinal fungi Cordyceps militaris, in aging-associated testicular inflammation and serum biochemical changes in naturally aged rats were investigated. Male Sprague Dawley rats were divided into young control (YC), aged control (AC), and COR (5, 10, and 20 mg/kg) treated aged rat groups. Aging-associated serum biochemical changes and inflammatory parameters were analyzed by biochemical assay kits, Western blotting, and real-time RT-PCR. Results showed a significant (p
ISSN:1229-8093