Comparing the Expression of Canonical and Non-Canonical Inflammasomes Across Glioma Grades: Evaluating Their Potential as an Aggressiveness Marker

Background Inflammasomes are key in the initiation of inflammatory responses and serve to defend the organism. However, when the immune system is imbalanced, these complexes contribute to tumor progression. The purpose of this study was to investigate the effect of non-canonical inflammasomes on gli...

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Bibliographic Details
Published in:Brain tumor research and treatment 2023-07, Vol.11 (3), p.191
Main Authors: Yu Jin Kim, Wooseok Choi, Jeongmin Sim, Ju Won Ahn, Jeongman Park, Dongkil Kim, Ju-yeon Jeong, Ji Min Lee, Kyunggi Cho, Jong-seok Moon, Ju Hyung Moon, Kyoung Su Sung, Jaejoon Lim
Format: Article
Language:Korean
Subjects:
Biomarkers
Disease progression
Glioma
Inflammasomes
Pyroptosis
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Summary:Background Inflammasomes are key in the initiation of inflammatory responses and serve to defend the organism. However, when the immune system is imbalanced, these complexes contribute to tumor progression. The purpose of this study was to investigate the effect of non-canonical inflammasomes on glioma malignancy. Methods We performed bioinformatics analysis to confirm the expression of canonical and non-canonical inflammasome-related molecules according to the degree of malignancy through immunohistochemical examination of glioma tissues obtained with patient consent from our institution. Results Bioinformatics analysis confirmed that the expression levels of non-canonical inflammasome- related molecules were significantly higher in tumor tissues than in normal tissues, and they also increased according to malignancy, which adversely affected the survival rate. Furthermore, in gliomas, positive correlations were found between N-form gasdermin-D, a key molecule associated with the non-canonical inflammasome, and other related molecules, including NLRP3, caspase-1, caspase- 4, and caspase-5. These results were verified by immunohistochemical examination of glioma tissues, and the expression levels of these molecules also increased significantly with increasing grade. In addition, the features of pyroptosis were confirmed. Conclusion This study identified the potential of non-canonical inflammasomes as aggressiveness markers for gliomas and presented a perspective for improving glioma treatment.
ISSN:2288-2405