Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis

Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, marked by gastrointestinal motility disorder, a delayed gastric emptying present in the absence of mechani...

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Bibliographic Details
Published in:Journal of neurogastroenterology and motility 2024-04, Vol.30 (2), p.143
Main Authors: Yu-xin Zhang, Yan-jiao Zhang, Min Li, Jia-xing Tian, Xiao-lin Tong
Format: Article
Language:Korean
Subjects:
Diabetes mellitus
Gastrointestinal hormones
Gastrointestinal motility
Gastroparesis
Interstitial cells of Cajal
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Summary:Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, marked by gastrointestinal motility disorder, a delayed gastric emptying present in the absence of mechanical obstruction. Clinical manifestations include postprandial fullness and epigastric discomfort, bloating, nausea, and vomiting. DGP may significantly affect the quality of life and productivity of patients. Research on the relationship between gastrointestinal dynamics and DGP has received much attention because of the increasing prevalence of DGP. Gastrointestinal motility disorders are closely related to a variety of factors including the absence and destruction of interstitial cells of Cajal, abnormalities in the neuro-endocrine system and hormone levels. Therefore, this study will review recent literature on the mechanisms of DGP and gastrointestinal motility disorders as well as the development of prokinetic treatment of gastrointestinal motility disorders in order to give future research directions and identify treatment strategies for DGP. (J Neurogastroenterol Motil 2024;30:143-155)
ISSN:2093-0879
2093-0887