Convenient Synthesis of Chiral trans-2-Phenylcyclopropanecarboxylic Acid

(-)-(1R, 2R) and (+)-(1S, 2S)-menthyl-trans-2-phenylcyclopropanecarboxylat e have been synthesized with the aid of chiral Cu(II) complex catalyst by the addition reaction of l-menthyldiazoacetate to styrene. The yield was 75%, with the purity of trans isomer over 95% and the optical purity of 95%.

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 1988, Vol.9 (4), p.195-198
Main Authors: Cho, Nam-Sook, Shin, Dae-Hyun, Lee, Chong-Chul, Ra, Do-Young
Format: Article
Language:Korean
Online Access:Get full text
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Summary:(-)-(1R, 2R) and (+)-(1S, 2S)-menthyl-trans-2-phenylcyclopropanecarboxylat e have been synthesized with the aid of chiral Cu(II) complex catalyst by the addition reaction of l-menthyldiazoacetate to styrene. The yield was 75%, with the purity of trans isomer over 95% and the optical purity of 95%.
ISSN:0253-2964
1229-5949