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Effect of Pyridoxine on Rifampicin Toxicity
The effects of pyridoxine (PN) on rifampicin (RMF) toxicity were investigated by both in vivo and in vitro methods. RMF (30 mg/kg) was injected intraperitoneally and PN(150 mg/kg) was administered orally to rats for 10 consecutive days. After treatment, clinical chemistry and hematologic profiles we...
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| Published in: | Archives of pharmacal research 1991, Vol.14 (1), p.73-77 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | Korean |
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| container_end_page | 77 |
| container_issue | 1 |
| container_start_page | 73 |
| container_title | Archives of pharmacal research |
| container_volume | 14 |
| creator | Yun, Yeo-Pyo Kim, Koan-Hoi Kim, Hack-Seang Chung, Jin-Ho |
| description | The effects of pyridoxine (PN) on rifampicin (RMF) toxicity were investigated by both in vivo and in vitro methods. RMF (30 mg/kg) was injected intraperitoneally and PN(150 mg/kg) was administered orally to rats for 10 consecutive days. After treatment, clinical chemistry and hematologic profiles were measured. RMF and PN plus RMF did not show any adverse effects at this in vivo experimental condition. Thymidine incorporations of mice bone marrow cells were examined in vitro. RMF showed a decrease in thymidine uptake in a dose-dependent manner, but PN showed a reversal of the thymidine uptake suppression caused by RMF (p |
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RMF (30 mg/kg) was injected intraperitoneally and PN(150 mg/kg) was administered orally to rats for 10 consecutive days. After treatment, clinical chemistry and hematologic profiles were measured. RMF and PN plus RMF did not show any adverse effects at this in vivo experimental condition. Thymidine incorporations of mice bone marrow cells were examined in vitro. RMF showed a decrease in thymidine uptake in a dose-dependent manner, but PN showed a reversal of the thymidine uptake suppression caused by RMF (p<0.01). 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RMF (30 mg/kg) was injected intraperitoneally and PN(150 mg/kg) was administered orally to rats for 10 consecutive days. After treatment, clinical chemistry and hematologic profiles were measured. RMF and PN plus RMF did not show any adverse effects at this in vivo experimental condition. Thymidine incorporations of mice bone marrow cells were examined in vitro. RMF showed a decrease in thymidine uptake in a dose-dependent manner, but PN showed a reversal of the thymidine uptake suppression caused by RMF (p<0.01). On the other hand, PN showed a decrease in thymidine uptake at a high concentration level.</abstract><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0253-6269 |
| ispartof | Archives of pharmacal research, 1991, Vol.14 (1), p.73-77 |
| issn | 0253-6269 1976-3786 |
| language | kor |
| recordid | cdi_kisti_ndsl_JAKO199103038901873 |
| source | Springer Online Journals Archive Complete |
| title | Effect of Pyridoxine on Rifampicin Toxicity |
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