Synthesis and Biological Activity of Poly[(tri-O-acetyl-D-glucal)-alt-(maleic anhydride)] Derivatives

Poly[(tri-O-acetyl-D-glucal)-alt-(maleic anhydride)] was synthesized by free radical copolymerizations of the relevant comonomers. The alternating sequence of the copolymer was confirmed by $^1$H-NMR, elemental analysis, and titration of anhydride groups incorporated into the copolymer. Hydrolysis o...

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Published in:Bulletin of the Korean Chemical Society 1991, Vol.12 (1), p.85-87
Main Authors: Han, Man-Jung, Lee, Choong-Whan, Kim, Ki-Ho, Lee, Won-Young
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Language:Korean
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container_title Bulletin of the Korean Chemical Society
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creator Han, Man-Jung
Lee, Choong-Whan
Kim, Ki-Ho
Lee, Won-Young
description Poly[(tri-O-acetyl-D-glucal)-alt-(maleic anhydride)] was synthesized by free radical copolymerizations of the relevant comonomers. The alternating sequence of the copolymer was confirmed by $^1$H-NMR, elemental analysis, and titration of anhydride groups incorporated into the copolymer. Hydrolysis of the copolymer under different conditions resulted in poly[(2-acetoxymethyl-3,4-diacetoxytetrahydropyran-5,6-diyl) (1,2-dicarboxyethylene)] and poly[(2-hydroxymethyl-3,4-dihydroxytetrahydropyran-5,6-diyl) (1,2-dicarboxyethylene)]. The cytotoxicities of these polymers measured against normal and tumor cells (3LL, B16) in vitro were found to be higher than that of DIVEMA, a prototype polymer having a high antitumor activity.
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title Synthesis and Biological Activity of Poly[(tri-O-acetyl-D-glucal)-alt-(maleic anhydride)] Derivatives
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