Synthesis and Antitumor Activity of 3-Arylisoquinoline Derivatives

In order to study the structure-activity relationship of 7, 8-dimethoxy-2-methyl-3-(4, 5-methylenedioxy-2-vinylphenyl)isoquinoline-1(2H) -one (2), which has exhibited significant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products (3-7). Further systema...

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Published in:Archives of pharmacal research 1997, Vol.20 (3), p.264-268
Main Authors: Cho, Won-Jea, Yoo, Su-Jeong, Park, Myun-Ji, Chung, Byung-Ho, Lee, Chong-Ock
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creator Cho, Won-Jea
Yoo, Su-Jeong
Park, Myun-Ji
Chung, Byung-Ho
Lee, Chong-Ock
description In order to study the structure-activity relationship of 7, 8-dimethoxy-2-methyl-3-(4, 5-methylenedioxy-2-vinylphenyl)isoquinoline-1(2H) -one (2), which has exhibited significant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested for in vitro antitumor activity against five different human cancer cell lines.
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title Synthesis and Antitumor Activity of 3-Arylisoquinoline Derivatives
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