Pheophorbide A-methyl Ester, Acyl-CoA: Cholesterol Acyltransferase Inhibitor from Diospyros kaki

In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl es...

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Bibliographic Details
Published in:Archives of pharmacal research 2003, Vol.26 (9), p.716-718
Main Authors: Rho, Mun-Chual, Chung, Mi-Yeon, Song, Hye-Young, Kwon, Oh-Eok, Lee, Seung-Woong, Baek, Jin-Ah, Jeune, Kyung-Hee, Kim, Koan-Hoi, Lee, Hyun-Sun, Kim, Young-Kook
Format: Article
Language:Korean
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Summary:In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an $IC_{50}$ value of 1.85 $\mu$ g/mL.
ISSN:0253-6269
1976-3786